Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System

As pulmonary drug deposition is a function of aerosol particle size distribution, it critical that the dynamics formation and maturation in pMDI sprays interim between generation inhalation are fully understood. This paper presents an approach to measure evaporative condensational fluxes volatile components water from solution droplets following using novel technique referred as Single Particle Electrodynamic Lung (SPEL). In doing so, evaporating shown capable acting condensation nuclei for water. Indeed, we show rapid vaporisation droplet directly correlated volume taken up by condensation. Furthermore, significant condense on model formulation (hydrofluoroalkane (HFA), ethanol glycerol) during ageing, displaying dramatic shift core composition species predominantly (non-volatile glycerol remained this case). yields with activity 0.98 at instance inhalation. The implications these results regional total explored International Commission Radiological Protection (ICRP) model, integrated semi-analytical treatment hygroscopic growth. Through this, upon produce markedly different dose profiles those lower activities point inspiration.